A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.

2.50
Hdl Handle:
http://hdl.handle.net/10143/77413
Title:
A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.
Authors:
Beyer, Mona K; Janvin, Carmen C; Larsen, Jan P; Aarsland, Dag
Citation:
Journal of neurology, neurosurgery, and psychiatry 2007, 78 (3):254-9
Additional Links:
http://jnnp.bmj.com/cgi/reprint/78/3/254

Full metadata record

DC FieldValue Language
dc.contributor.authorBeyer, Mona K-
dc.contributor.authorJanvin, Carmen C-
dc.contributor.authorLarsen, Jan P-
dc.contributor.authorAarsland, Dag-
dc.date.accessioned2009-08-14T12:18:45Z-
dc.date.available2009-08-14T12:18:45Z-
dc.date.issued2007-03-
dc.identifier.citationJournal of neurology, neurosurgery, and psychiatry 2007, 78 (3):254-9en
dc.identifier.issn1468-330X-
dc.identifier.pmid17028119-
dc.identifier.doi10.1136/jnnp.2006.093849-
dc.identifier.urihttp://hdl.handle.net/10143/77413-
dc.description.abstractBACKGROUND: Dementia is common in Parkinson's disease, but the underlying brain pathology is not yet fully understood. AIM: To examine the changes in the brain of patients with Parkinson's disease with mild cognitive impairment (MCI) and dementia, using structural magnetic resonance imaging. METHODS: Using voxel-based morphometry, the grey matter atrophy on brain images of patients with Parkinson's disease and dementia (PDD; n = 16) and Parkinson's disease without dementia (PDND; n = 20), and healthy elderly subjects (n = 20) was studied. In the PDND group, 12 subjects had normal cognitive status and 8 had MCI. Standardised rating scales for motor, cognitive and psychiatric symptoms were used. RESULTS: Widespread areas of cortical atrophy were found in patients with PDD compared with normal controls (in both temporal and frontal lobes and in the left parietal lobe). Grey matter reductions were found in frontal, parietal, limbic and temporal lobes in patients with PDD compared with those with PDND. In patients with PDND with MCI, areas of reduced grey matter in the left frontal and both temporal lobes were found. CONCLUSION: These findings show that dementia in Parkinson's disease is associated with structural neocortical changes in the brain, and that cognitive impairment in patients with PDND may be associated with structural changes in the brain. Further studies with larger groups of patients are needed to confirm these findings.en
dc.language.isoenen
dc.relation.urlhttp://jnnp.bmj.com/cgi/reprint/78/3/254en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752en
dc.subject.meshAgeden
dc.subject.meshBrainen
dc.subject.meshCase-Control Studiesen
dc.subject.meshCognition Disordersen
dc.subject.meshDementiaen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshMaleen
dc.subject.meshParkinson Diseaseen
dc.titleA magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentDepartment of Radiology, Stavanger University Hospital, PO Box 8100, N-4068 Stavanger, Norway. bemk@sus.noen
dc.identifier.journalJournal of neurology, neurosurgery, and psychiatryen
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