Expressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis.

2.50
Hdl Handle:
http://hdl.handle.net/10143/72173
Title:
Expressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis.
Authors:
Holm, Ruth; de Putte, Gregg Van; Suo, Zhenhe; Lie, A Kathrine; Kristensen, Gunnar B
Citation:
International journal of medical sciences 2008, 5 (3):121-6
Additional Links:
http://www.medsci.org/v05p0121.pdf

Full metadata record

DC FieldValue Language
dc.contributor.authorHolm, Ruth-
dc.contributor.authorde Putte, Gregg Van-
dc.contributor.authorSuo, Zhenhe-
dc.contributor.authorLie, A Kathrine-
dc.contributor.authorKristensen, Gunnar B-
dc.date.accessioned2009-07-02T08:39:49Z-
dc.date.available2009-07-02T08:39:49Z-
dc.date.issued2008-
dc.identifier.citationInternational journal of medical sciences 2008, 5 (3):121-6en
dc.identifier.issn1449-1907-
dc.identifier.pmid18566674-
dc.identifier.urihttp://hdl.handle.net/10143/72173-
dc.description.abstractBy using immunohistochemistry we investigated the expression of EphA2 and EphrinA-1 in 217 early squamous cell cervical carcinomas and examine their prognostic relevance. For EphA2 expression, 21 tumors (10%) showed negative, 108 (50%) weak positive, 69 (32%) moderate positive and 19 (9%) strong positive, whereas for EphrinA-1 expression, 33 tumors (15%) showed negative, 91 (42%) weak positive, 67 (31%) moderate positive and 26 (12%) strong positive. In univariate analysis high expression (strong staining) of EphrinA-1 was associated with poor disease-free (P = 0.033) and disease-specific (P = 0.039) survival. However, in the multivariate analyses neither EphrinA-1 nor EphA2 was significantly associated to survival. The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers. However, EphA2 and EphrinA-1 were not independently associated with clinical outcome.en
dc.language.isoenen
dc.relation.urlhttp://www.medsci.org/v05p0121.pdfen
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762en
dc.subject.meshAdulten
dc.subject.meshCarcinoma, Squamous Cellen
dc.subject.meshDisease-Free Survivalen
dc.subject.meshEphrin-A1en
dc.subject.meshEphrin-A2en
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshImmunohistochemistryen
dc.subject.meshMiddle Ageden
dc.subject.meshModels, Biologicalen
dc.subject.meshPrognosisen
dc.subject.meshRetrospective Studiesen
dc.subject.meshTreatment Outcomeen
dc.subject.meshUterine Cervical Neoplasmsen
dc.titleExpressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentDivision of Pathology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway. ruth.holm@radiumhospitalet.noen
dc.identifier.journalInternational journal of medical sciencesen
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