Cortisol level predicts executive and memory function in depression, symptom-level predicts psychomotor speed.

2.50
Hdl Handle:
http://hdl.handle.net/10143/71774
Title:
Cortisol level predicts executive and memory function in depression, symptom-level predicts psychomotor speed.
Authors:
Egeland, Jens; Lund, Anders; Landrø, Nils Inge; Rund, Bjørn Rishovd; Sundet, K; Asbjørnsen, A; Mjellem, N; Roness, Atle; Stordal, Kirsten I
Citation:
Acta psychiatrica Scandinavica 2005, 112 (6):434-41

Full metadata record

DC FieldValue Language
dc.contributor.authorEgeland, Jens-
dc.contributor.authorLund, Anders-
dc.contributor.authorLandrø, Nils Inge-
dc.contributor.authorRund, Bjørn Rishovd-
dc.contributor.authorSundet, K-
dc.contributor.authorAsbjørnsen, A-
dc.contributor.authorMjellem, N-
dc.contributor.authorRoness, Atle-
dc.contributor.authorStordal, Kirsten I-
dc.date.accessioned2009-06-29T08:31:57Z-
dc.date.available2009-06-29T08:31:57Z-
dc.date.issued2005-12-
dc.identifier.citationActa psychiatrica Scandinavica 2005, 112 (6):434-41en
dc.identifier.issn0001-690X-
dc.identifier.pmid16279872-
dc.identifier.doi10.1111/j.1600-0447.2005.00599.x-
dc.identifier.urihttp://hdl.handle.net/10143/71774-
dc.description.abstractOBJECTIVE: On a group level depression is related to hypercortisolism and to psychomotor retardation, executive dysfunction and memory impairment. However, intra-group heterogeneity is substantial. Why some are impaired while others remain in the normal range, is not clear. The present study aims at discerning the relative contribution of present symptom severity and hypercortisolism to impairment in the three domains of cognition. METHOD: Morning saliva cortisol was measured in 26 subjects with recurrent major depression prior to a neuropsychological examination with tests known to be sensitive to cognitive impairment in depression. RESULTS: Cortisol level correlated with executive dysfunction and post-encoding memory deficits, but not with processing speed. Depression level correlated with processing speed. These patterns remained significant after controlling for confounders through partial correlations. CONCLUSION: The association between cortisol and cognition is not an artifact of psychiatric symptom load. High level of saliva cortisol is associated with aspects of cognition that can be dissociated from psychomotor retardation, which is dependent on symptom load.en
dc.language.isoenen
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en
dc.subject.meshAdulten
dc.subject.meshCognitionen
dc.subject.meshDepressive Disorder, Majoren
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshHydrocortisoneen
dc.subject.meshMaleen
dc.subject.meshMemoryen
dc.subject.meshMental Processesen
dc.subject.meshMiddle Ageden
dc.subject.meshPredictive Value of Testsen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshSalivaen
dc.subject.meshSeverity of Illness Indexen
dc.titleCortisol level predicts executive and memory function in depression, symptom-level predicts psychomotor speed.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentVestfold Mental Health Care Trust, Tønsberg, Norway. jens.egeland@piv.noen
dc.identifier.journalActa psychiatrica Scandinavicaen

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