Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome.

2.50
Hdl Handle:
http://hdl.handle.net/10143/67353
Title:
Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome.
Authors:
Haugaa, Kristina Hermann; Edvardsen, Thor; Leren, Trond P; Gran, Jon Michael; Smiseth, Otto A; Amlie, Jan P
Citation:
European heart journal 2009, 30 (3):330-7
Additional Links:
http://eurheartj.oxfordjournals.org/cgi/content/full/30/3/330

Full metadata record

DC FieldValue Language
dc.contributor.authorHaugaa, Kristina Hermann-
dc.contributor.authorEdvardsen, Thor-
dc.contributor.authorLeren, Trond P-
dc.contributor.authorGran, Jon Michael-
dc.contributor.authorSmiseth, Otto A-
dc.contributor.authorAmlie, Jan P-
dc.date.accessioned2009-05-06T07:25:52Z-
dc.date.available2009-05-06T07:25:52Z-
dc.date.issued2009-02-
dc.identifier.citationEuropean heart journal 2009, 30 (3):330-7en
dc.identifier.issn1522-9645-
dc.identifier.pmid18940888-
dc.identifier.doi10.1093/eurheartj/ehn466-
dc.identifier.urihttp://hdl.handle.net/10143/67353-
dc.description.abstractAIMS: The aim of this study was to investigate whether prolonged and dispersed myocardial contraction duration assessed by tissue Doppler imaging (TDI) may serve as risk markers for cardiac events (documented arrhythmia, syncope, and cardiac arrest) in patients with long QT syndrome (LQTS). METHODS AND RESULTS: Seventy-three patients with genetically confirmed LQTS (nine double- and 33 single-mutation carriers with previous cardiac events and 31 single-mutation carriers without events) were studied. Myocardial contraction duration was prolonged in each group of LQTS patients compared with 20 healthy controls (P < 0.001). Contraction duration was longer in single-mutation carriers with previous cardiac events compared with those without (0.46 +/- 0.06 vs. 0.40 +/- 0.06 s, P = 0.001). Prolonged contraction duration could better identify cardiac events compared with corrected QT (QTc) interval in single-mutation carriers [area under curve by receiver-operating characteristic analysis 0.77 [95% confidence interval (95% CI) 0.65-0.89] vs. 0.66 (95% CI 0.52-0.79)]. Dispersion of contraction was more pronounced in single-mutation carriers with cardiac events compared with those without (0.048 +/- 0.018 vs. 0.031 +/- 0.019 s, P = 0.001). CONCLUSION: Dispersion of myocardial contraction assessed by TDI was increased in LQTS patients. Prolonged contraction duration was superior to QTc for risk assessment. These new methods can easily be implemented in clinical routine and may improve clinical management of LQTS patients.en
dc.language.isoenen
dc.relation.urlhttp://eurheartj.oxfordjournals.org/cgi/content/full/30/3/330en
dc.subjectKardiologien
dc.subject.meshAdolescenten
dc.subject.meshAdrenergic beta-Antagonistsen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshChilden
dc.subject.meshEchocardiography, Doppleren
dc.subject.meshHeart Arresten
dc.subject.meshHumansen
dc.subject.meshLong QT Syndromeen
dc.subject.meshMiddle Ageden
dc.subject.meshMutationen
dc.subject.meshMyocardial Contractionen
dc.subject.meshRisk Assessmenten
dc.subject.meshSyncopeen
dc.subject.meshVentricular Function, Leften
dc.subject.meshYoung Adulten
dc.titleLeft ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentDepartment of Cardiology, Rikshospitalet University Hospital, University of Oslo, N-0027 Oslo, Norway.en
dc.identifier.journalEuropean heart journalen
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