The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.

2.50
Hdl Handle:
http://hdl.handle.net/10143/67073
Title:
The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.
Authors:
Wang, Zhihui; Tropè, Claes G; Suo, Zhenhe; Trøen, Gunhild; Yang, Guanrui; Nesland, Jahn M; Holm, Ruth
Citation:
BMC cancer 2008, 8:308
Additional Links:
http://www.biomedcentral.com/1471-2407/8/308

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Zhihui-
dc.contributor.authorTropè, Claes G-
dc.contributor.authorSuo, Zhenhe-
dc.contributor.authorTrøen, Gunhild-
dc.contributor.authorYang, Guanrui-
dc.contributor.authorNesland, Jahn M-
dc.contributor.authorHolm, Ruth-
dc.date.accessioned2009-05-05T07:22:26Z-
dc.date.available2009-05-05T07:22:26Z-
dc.date.issued2008-
dc.identifier.citationBMC cancer 2008, 8:308en
dc.identifier.issn1471-2407-
dc.identifier.pmid18950492-
dc.identifier.doi10.1186/1471-2407-8-308-
dc.identifier.urihttp://hdl.handle.net/10143/67073-
dc.description.abstractBACKGROUND: 14-3-3 sigma promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3sigma, which has been demonstrated in various carcinomas, may contribute to malignant transformation. However, the exact role of 14-3-3sigma in the pathogenesis of vulvar carcinoma is not fully characterized, and the prognostic impact of 14-3-3sigma protein expression is still unknown. METHODS: We investigated the 14-3-3sigma expression in a series of 302 vulvar squamous cell carcinomas using immunohistochemistry and its associations with clinicopathological factors and clinical outcome. RESULTS: In cytoplasm, nucleus and cytoplasm/nucleus of vulvar carcinomas high 14-3-3sigma protein expression was found in 72%, 59% and 75% of the carcinomas, respectively, and low levels in 28%, 41% and 25% of the cases, respectively. High level of 14-3-3sigma in cytoplasm, nucleus and cytoplasm/nucleus was significantly correlated to large tumor diameter (p = 0.001, p = 0.002 and p = 0.001, respectively) and deep invasion (p = 0.01, p = 0.001 and p = 0.007, respectively). Variations of 14-3-3sigma protein expression were not associated to disease-specific survival. CONCLUSION: Our results indicate that 14-3-3sigma may be involved in the development of a subset of vulvar squamous cell carcinomas by down-regulation of 14-3-3sigma protein. Neither cytoplasmic nor nuclear level of 14-3-3sigma expression was associated with prognosis.en
dc.language.isoenen
dc.relation.urlhttp://www.biomedcentral.com/1471-2407/8/308en
dc.subjectonkologien
dc.subject.meshAdulten
dc.titleThe clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentDivision of Pathology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway. zhihui.wang@radiumhospitalet.noen
dc.identifier.journalBMC canceren
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