Disruption of Vps4 and JNK function in Drosophila causes tumour growth.

2.50
Hdl Handle:
http://hdl.handle.net/10143/55853
Title:
Disruption of Vps4 and JNK function in Drosophila causes tumour growth.
Authors:
Rodahl, Lina M; Haglund, Kaisa; Sem-Jacobsen, Catherine; Wendler, Franz; Vincent, Jean-Paul; Lindmo, Karine; Rusten, Tor Erik; Stenmark, Harald
Citation:
PLoS ONE 2009, 4 (2):e4354
Additional Links:
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0004354

Full metadata record

DC FieldValue Language
dc.contributor.authorRodahl, Lina M-
dc.contributor.authorHaglund, Kaisa-
dc.contributor.authorSem-Jacobsen, Catherine-
dc.contributor.authorWendler, Franz-
dc.contributor.authorVincent, Jean-Paul-
dc.contributor.authorLindmo, Karine-
dc.contributor.authorRusten, Tor Erik-
dc.contributor.authorStenmark, Harald-
dc.date.accessioned2009-03-17T09:52:15Z-
dc.date.available2009-03-17T09:52:15Z-
dc.date.issued2009-
dc.identifier.citationPLoS ONE 2009, 4 (2):e4354en
dc.identifier.issn1932-6203-
dc.identifier.pmid19194501-
dc.identifier.doi10.1371/journal.pone.0004354-
dc.identifier.urihttp://hdl.handle.net/10143/55853-
dc.description.abstractSeveral regulators of endocytic trafficking have recently been identified as tumour suppressors in Drosophila. These include components of the endosomal sorting complex required for transport (ESCRT) machinery. Disruption of subunits of ESCRT-I and -II leads to cell-autonomous endosomal accumulation of ubiquitinated receptors, loss of apicobasal polarity and epithelial integrity, and increased cell death. Here we report that disruption of the ATPase dVps4, the most downstream component of the ESCRT machinery, causes the same array of cellular phenotypes. We find that loss of epithelial integrity and increased apoptosis, but not loss of cell polarity, require the activation of JNK signalling. Abrogation of JNK signalling prevents apoptosis in dVps4 deficient cells. Indeed double deficiency in dVps4 and JNK signalling leads to the formation of neoplastic tumours. We conclude that dvps4 is a tumour suppressor in Drosophila and that JNK is central to the cell-autonomous phenotypes of ESCRT-deficient cells.en
dc.language.isoenen
dc.relation.urlhttp://www.plosone.org/article/info:doi/10.1371/journal.pone.0004354en
dc.subjectOnkologi: 762en
dc.titleDisruption of Vps4 and JNK function in Drosophila causes tumour growth.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentFaculty of Medicine, Centre for Cancer Biomedicine, University of Oslo and Institute for Cancer Research, the Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, Oslo, Norway.en
dc.identifier.journalPLoS ONEen
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