Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour.

2.50
Hdl Handle:
http://hdl.handle.net/10143/42073
Title:
Congenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour.
Authors:
Oerbeck, Beate; Sundet, Kjetil; Kase, Bengt Frode; Heyerdahl, Sonja
Citation:
Archives of disease in childhood 2005, 90 :132-7
Additional Links:
http://adc.bmj.com/cgi/reprint/90/2/132.pdf; http://adc.bmj.com/content/vol90/issue2/

Full metadata record

DC FieldValue Language
dc.contributor.authorOerbeck, Beate-
dc.contributor.authorSundet, Kjetil-
dc.contributor.authorKase, Bengt Frode-
dc.contributor.authorHeyerdahl, Sonja-
dc.date.accessioned2008-12-09T09:50:38Z-
dc.date.available2008-12-09T09:50:38Z-
dc.date.issued2005-02-
dc.identifier.citationArchives of disease in childhood 2005, 90 :132-7en
dc.identifier.issn1468-2044-
dc.identifier.pmid15665163-
dc.identifier.doi10.1136/adc.2003.043935-
dc.identifier.urihttp://hdl.handle.net/10143/42073-
dc.description.abstractBACKGROUND: In congenital hypothyroidism (CH) it has been questioned whether high dose thyroxine replacement therapy has detrimental effects on memory, attention, and behaviour. AIMS: To describe memory, attention, and behaviour problems in young adults with CH, and to study possible negative effects of high dose thyroxine replacement therapy. METHODS: A cohort based follow up study of 49 young adults (mean age 20 years) with early treated CH, and sibling controls (n = 41). RESULTS: Controlled for age and sex, the CH group attained significantly lower scores than sibling controls on some tests of memory (Wechsler Logical Memory part II: 12.9 versus 17.8; difference 5.2, 95% CI 3.6 to 6.8) and attention (Wechsler Freedom From Distractibility factor: 95.6 versus 104.8; difference 9.9, 95% CI 6.4 to 13.4). They rated themselves with more behaviour problems than did sibling controls (52.7 versus 44.7; difference -7.6, 95% CI -11.2 to -4.0) on the Achenbach Self Report. A high thyroxine starting dose, high serum thyroxine treatment levels during the first six childhood years, and high levels at assessment had no adverse effects on outcome measures at age 20. On the contrary, the results suggest better outcome with higher childhood treatment levels. CONCLUSIONS: Long term outcome revealed deficits in some aspects of memory, attention, and behaviour in young adults with CH relative to sibling controls. No adverse effects of high dose thyroxine therapy were found on measures of memory, attention, and behaviour problems.en
dc.language.isoenen
dc.relation.urlhttp://adc.bmj.com/cgi/reprint/90/2/132.pdf-
dc.relation.urlhttp://adc.bmj.com/content/vol90/issue2/-
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Psykiatri, barnepsykiatri: 757en
dc.subject.meshAdulten
dc.subject.meshAnalysis of Varianceen
dc.subject.meshAttentionen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshCongenital Hypothyroidismen
dc.subject.meshDrug Administration Scheduleen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHumansen
dc.subject.meshHypothyroidismen
dc.subject.meshMaleen
dc.subject.meshMemory Disordersen
dc.subject.meshMental Disordersen
dc.subject.meshNeuropsychological Testsen
dc.subject.meshThyroxineen
dc.subject.meshTreatment Outcomeen
dc.titleCongenital hypothyroidism: no adverse effects of high dose thyroxine treatment on adult memory, attention, and behaviour.en
dc.typepeer reviewed-
dc.typeJournal article-
dc.contributor.departmentCentre for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway. beate.orbeck@r-bup.noen
dc.identifier.journalArchives of disease in childhooden
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