Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT).

2.50
Hdl Handle:
http://hdl.handle.net/10143/41678
Title:
Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT).
Authors:
Bækken, Petter M; Skorpen, Frank; Stordal, Eystein; Zwart, John-Anker; Hagen, Knut
Citation:
BMC psychiatry 2008, 8:48
Additional Links:
http://www.biomedcentral.com/1471-244X/8/48

Full metadata record

DC FieldValue Language
dc.contributor.authorBækken, Petter M-
dc.contributor.authorSkorpen, Frank-
dc.contributor.authorStordal, Eystein-
dc.contributor.authorZwart, John-Anker-
dc.contributor.authorHagen, Knut-
dc.date.accessioned2008-12-02T10:07:57Z-
dc.date.available2008-12-02T10:07:57Z-
dc.date.issued2008-
dc.identifier.citationBMC psychiatry 2008, 8:48en
dc.identifier.issn1471-244X-
dc.identifier.pmid18578865-
dc.identifier.doi10.1186/1471-244X-8-48-
dc.identifier.urihttp://hdl.handle.net/10143/41678-
dc.description.abstractBACKGROUND: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present study was to examine the relationship between the Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital Anxiety and Depression Scale (HADS) in the general adult population. METHODS: In the Nord-Trøndelag Health Study (HUNT) the association between the Val158Met polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals. Two different cut off scores (> or = 8 and > or = 11) were used to identify cases with anxiety (HADS-A) and depression (HADS-D), whereas controls had HADS-A <8 and HADS-D <8. RESULTS: The COMT genotype distribution was similar between controls and individuals in the groups with anxiety and depression using cut-off scores of > or = 8. When utilizing the alternative cut-off score HADS-D > or = 11, Met/Met genotype and Met allele were less common among men with depression compared to the controls (genotype: p = 0.017, allele: p = 0.006). In the multivariate analysis, adjusting for age and heart disease, depression (HADS-D > or = 11) was less likely among men with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI = 0.18-0.76). CONCLUSION: In this population-based study, no clear association between the Val158Met polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely among men with depression defined as HADS-D > or = 11, but this may be an incidental finding.en
dc.language.isoenen
dc.relation.urlhttp://www.biomedcentral.com/1471-244X/8/48en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en
dc.subject.meshAdulten
dc.subject.meshAnxiety Disordersen
dc.subject.meshCatechol O-Methyltransferaseen
dc.subject.meshChromosomes, Human, Pair 22en
dc.subject.meshDepressive Disorder, Majoren
dc.subject.meshFemaleen
dc.subject.meshGene Expressionen
dc.subject.meshGenotypeen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPolymorphism, Geneticen
dc.subject.meshPopulation Surveillanceen
dc.subject.meshQuestionnairesen
dc.titleDepression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: the Nord-Trøndelag Health Study (HUNT).en
dc.typepeer revieweden
dc.contributor.departmentDepartment of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. petterb@stud.ntnu.noen
dc.contributor.departmentUllevaal University Hospitalen
dc.identifier.journalBMC psychiatryen
All Items in HeRA are protected by copyright, with all rights reserved, unless otherwise indicated.