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Grading quality of evidence and strength of recommendations.
Atkins, David; Best, Dana; Briss, Peter A; Eccles, Martin; Falck-Ytter, Yngve; Flottorp, Signe; Guyatt, Gordon H; Harbour, Robin T; Haugh, Margaret C; Henry, David; Hill, Suzanne; Jaeschke, Roman; Leng, Gillian; Liberati, Alessandro; Magrini, Nicola; Mason, James; Middleton, Philippa; Mrukowicz, Jacek; O'Connell, Dianne; Oxman, Andrew David; Phillips, Bob; Schünemann, Holger J; Edejer, Tessa Tan-Torres; Varonen, Helena; Vist, Gunn Elisabeth; Williams, John W; Zaza, Stephanie
BMJ 2004, 328 (7454):1490
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dc.contributor.authorAtkins, David-
dc.contributor.authorBest, Dana-
dc.contributor.authorBriss, Peter A-
dc.contributor.authorEccles, Martin-
dc.contributor.authorFalck-Ytter, Yngve-
dc.contributor.authorFlottorp, Signe-
dc.contributor.authorGuyatt, Gordon H-
dc.contributor.authorHarbour, Robin T-
dc.contributor.authorHaugh, Margaret C-
dc.contributor.authorHenry, David-
dc.contributor.authorHill, Suzanne-
dc.contributor.authorJaeschke, Roman-
dc.contributor.authorLeng, Gillian-
dc.contributor.authorLiberati, Alessandro-
dc.contributor.authorMagrini, Nicola-
dc.contributor.authorMason, James-
dc.contributor.authorMiddleton, Philippa-
dc.contributor.authorMrukowicz, Jacek-
dc.contributor.authorO'Connell, Dianne-
dc.contributor.authorOxman, Andrew David-
dc.contributor.authorPhillips, Bob-
dc.contributor.authorSchünemann, Holger J-
dc.contributor.authorEdejer, Tessa Tan-Torres-
dc.contributor.authorVaronen, Helena-
dc.contributor.authorVist, Gunn Elisabeth-
dc.contributor.authorWilliams, John W-
dc.contributor.authorZaza, Stephanie-
dc.identifier.citationBMJ 2004, 328 (7454):1490en
dc.description.abstractUsers of clinical practice guidelines and other recommendations need to know how much confidence they can place in the recommendations. Systematic and explicit methods of making judgments can reduce errors and improve communication. We have developed a system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts. In this article we present a summary of our approach from the perspective of a guideline user. Judgments about the strength of a recommendation require consideration of the balance between benefits and harms, the quality of the evidence, translation of the evidence into specific circumstances, and the certainty of the baseline risk. It is also important to consider costs (resource utilisation) before making a recommendation. Inconsistencies among systems for grading the quality of evidence and the strength of recommendations reduce their potential to facilitate critical appraisal and improve communication of these judgments. Our system for guiding these complex judgments balances the need for simplicity with the need for full and transparent consideration of all important issues.en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Helsetjeneste- og helseadministrasjonsforskning: 806en
dc.subject.meshCost-Benefit Analysisen
dc.subject.meshEvidence-Based Medicineen
dc.subject.meshPractice Guidelines as Topicen
dc.subject.meshQuality Assurance, Health Careen
dc.titleGrading quality of evidence and strength of recommendations.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.identifier.journalBMJ (Clinical research ed.)en
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