Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study.

2.50
Hdl Handle:
http://hdl.handle.net/10143/30052
Title:
Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study.
Authors:
Skjelbred, Camilla F; Sæbø, Mona; Nexø, Bjørn A; Wallin, Håkan; Hansteen, Inger-Lise; Vogel, Ulla; Kure, Elin H
Citation:
BMC cancer 2006, 6:175

Full metadata record

DC FieldValue Language
dc.contributor.authorSkjelbred, Camilla F-
dc.contributor.authorSæbø, Mona-
dc.contributor.authorNexø, Bjørn A-
dc.contributor.authorWallin, Håkan-
dc.contributor.authorHansteen, Inger-Lise-
dc.contributor.authorVogel, Ulla-
dc.contributor.authorKure, Elin H-
dc.date.accessioned2008-06-16T08:13:43Z-
dc.date.available2008-06-16T08:13:43Z-
dc.date.issued2006-
dc.identifier.citationBMC cancer 2006, 6:175en
dc.identifier.issn1471-2407-
dc.identifier.pmid16817948-
dc.identifier.doi10.1186/1471-2407-6-175-
dc.identifier.urihttp://hdl.handle.net/10143/30052-
dc.description.abstractBACKGROUND: The risk of sporadic colorectal cancer is mainly associated with lifestyle factors and may be modulated by several genetic factors of low penetrance. Genetic variants represented by single nucleotide polymorphisms in genes encoding key players in the adenoma carcinoma sequence may contribute to variation in susceptibility to colorectal cancer. In this study, we aimed to evaluate whether the recently identified haplotype encompassing genes of DNA repair and apoptosis, is associated with increased risk of colorectal adenomas and carcinomas. METHODS: We used a case-control study design (156 carcinomas, 981 adenomas and 399 controls) to test the association between polymorphisms in the chromosomal region 19q13.2-3, encompassing the genes ERCC1, ASE-1 and RAI, and risk of colorectal adenomas and carcinomas in a Norwegian cohort. Odds ratio (OR) and 95% confidence interval (CI) were estimated by binary logistic regression model adjusting for age and gender. RESULTS: The ASE-1 polymorphism was associated with an increased risk of adenomas, OR of 1.39 (95% CI 1.06-1.81), which upon stratification was apparent among women only, OR of 1.66 (95% CI 1.15-2.39). The RAI polymorphism showed a trend towards risk reduction for both adenomas (OR of 0.70, 95% CI 0.49-1.01) and carcinomas (OR of 0.49, 95% CI 0.21-1.13) among women, although not significant. Women who were homozygous carriers of the high risk haplotype had an increased risk of colorectal cancer, OR of 2.19 (95% CI 0.95-5.04) compared to all non-carriers although the estimate was not statistically significant. CONCLUSION: We found no evidence that the studied polymorphisms were associated with risk of adenomas or colorectal cancer among men, but we found weak indications that the chromosomal region may influence risk of colorectal cancer and adenoma development in women.en
dc.language.isoenen
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en
dc.subject.meshAdenomaen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshApoptosisen
dc.subject.meshCarcinomaen
dc.subject.meshCase-Control Studiesen
dc.subject.meshChromosomes, Human, Pair 19en
dc.subject.meshColorectal Neoplasmsen
dc.subject.meshDNA Repairen
dc.subject.meshDNA-Binding Proteinsen
dc.subject.meshEndonucleasesen
dc.subject.meshFemaleen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshIntracellular Signaling Peptides and Proteinsen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshOdds Ratioen
dc.subject.meshPolymorphism, Geneticen
dc.subject.meshRisk Factorsen
dc.subject.meshSex Factorsen
dc.titleEffects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentDepartment of Laboratory Medicine, Section of Medical Genetics, Telemark Hospital, N-3710 Skien, Norway. camilla-furu.skjelbred@sthf.noen
dc.contributor.departmentUllevaal University Hospitalen
dc.identifier.journalBMC canceren
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