Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10143/141770
Title:
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.
Authors:
Haabeth, Ole Audun Werner; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian M; Haraldsen, Guttorm; Bogen, Bjarne; Corthay, Alexandre
Citation:
Nature communications 2011, 2:240

Full metadata record

DC FieldValue Language
dc.contributor.authorHaabeth, Ole Audun Werneren
dc.contributor.authorLorvik, Kristina Bergen
dc.contributor.authorHammarström, Claraen
dc.contributor.authorDonaldson, Ian Men
dc.contributor.authorHaraldsen, Guttormen
dc.contributor.authorBogen, Bjarneen
dc.contributor.authorCorthay, Alexandreen
dc.date.accessioned2011-09-06T08:25:33Z-
dc.date.available2011-09-06T08:25:33Z-
dc.date.issued2011-
dc.identifier.citationNature communications 2011, 2:240en
dc.identifier.issn2041-1723-
dc.identifier.pmid21407206-
dc.identifier.doi10.1038/ncomms1239-
dc.identifier.urihttp://hdl.handle.net/10143/141770-
dc.description.abstractThe immune system can both promote and suppress cancer. Chronic inflammation and proinflammatory cytokines such as interleukin (IL)-1 and IL-6 are considered to be tumour promoting. In contrast, the exact nature of protective antitumour immunity remains obscure. Here, we quantify locally secreted cytokines during primary immune responses against myeloma and B-cell lymphoma in mice. Strikingly, successful cancer immunosurveillance mediated by tumour-specific CD4(+) T cells is consistently associated with elevated local levels of both proinflammatory (IL-1α, IL-1β and IL-6) and T helper 1 (Th1)-associated cytokines (interferon-γ (IFN-γ), IL-2 and IL-12). Cancer eradication is achieved by a collaboration between tumour-specific Th1 cells and tumour-infiltrating, antigen-presenting macrophages. Th1 cells induce secretion of IL-1β and IL-6 by macrophages. Th1-derived IFN-γ is shown to render macrophages directly cytotoxic to cancer cells, and to induce macrophages to secrete the angiostatic chemokines CXCL9/MIG and CXCL10/IP-10. Thus, inflammation, when driven by tumour-specific Th1 cells, may prevent rather than promote cancer.en
dc.language.isoenen
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en
dc.subject.meshAngiostatic Proteinsen
dc.subject.meshAnimalsen
dc.subject.meshCD4-Positive T-Lymphocytesen
dc.subject.meshCell Line, Tumoren
dc.subject.meshChemokine CXCL10en
dc.subject.meshChemokine CXCL9en
dc.subject.meshImmunohistochemistryen
dc.subject.meshInflammationen
dc.subject.meshInterferon-gammaen
dc.subject.meshInterleukin-12en
dc.subject.meshInterleukin-1alphaen
dc.subject.meshInterleukin-1betaen
dc.subject.meshInterleukin-2en
dc.subject.meshInterleukin-6en
dc.subject.meshLymphoma, B-Cellen
dc.subject.meshMacrophagesen
dc.subject.meshMiceen
dc.subject.meshMice, SCIDen
dc.subject.meshMultiple Myelomaen
dc.subject.meshNeoplasmsen
dc.subject.meshSignal Transductionen
dc.subject.meshTh1 Cellsen
dc.subject.meshTh2 Cellsen
dc.subject.meshTumor Microenvironmenten
dc.titleInflammation driven by tumour-specific Th1 cells protects against B-cell cancer.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentCentre for Immune Regulation, Institute of Immunology, University of Oslo and Oslo University Hospital Rikshospitalet, Oslo, Norway.en
dc.identifier.journalNature communicationsen
All Items in HeRA are protected by copyright, with all rights reserved, unless otherwise indicated.