Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse.

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Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse.
Kveberg, Lise; Dai, Ke-Zheng; Inngjerdingen, Marit; Brooks, Colin G; Fossum, Sigbjørn; Vaage, John T
Immunogenetics 2011, 63 (7):429-36 Immunogenetics

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dc.contributor.authorKveberg, Liseen
dc.contributor.authorDai, Ke-Zhengen
dc.contributor.authorInngjerdingen, Mariten
dc.contributor.authorBrooks, Colin Gen
dc.contributor.authorFossum, Sigbjørnen
dc.contributor.authorVaage, John Ten
dc.identifier.citationImmunogenetics 2011, 63 (7):429-36 Immunogeneticsen
dc.description.abstractTwo clusters of rat Nkrp1 genes can be distinguished based on phylogenetic relationships and functional characteristics. The proximal (centromeric) cluster encodes the well-studied NKR-P1A and NKR-P1B receptors and the distal cluster, the largely uncharacterized, NKR-P1F and NKR-P1G receptors. The inhibitory NKR-P1G receptor is expressed only by the Ly49s3(+) NK cell subset as detected by RT-PCR, while the activating NKR-P1F receptor is detected in both Ly49s3(+) and NKR-P1B(+) NK cells. The mouse NKR-P1G ortholog is expressed by both NKR-P1D(-) and NKR-P1D(+) NK cells in C57BL/6 mice. The rat and mouse NKR-P1F and NKR-P1G receptors demonstrate a striking, cross-species conservation of specificity for Clr ligands. NKR-P1F and NKR-P1G reporter cells reacted with overlapping panels of tumour cell lines and with cells transiently transfected with rat Clr2, Clr3, Clr4, Clr6 and Clr7 and mouse Clrc, Clrf, Clrg and Clrd/x, but not with Clr11 or Clrb, which serve as ligands for NKR-P1 from the proximal cluster. These data suggest that the conserved NKR-P1F and NKR-P1G receptors function as promiscuous receptors for a rapidly evolving family of Clr ligands in rodent NK cells.en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en
dc.subject.meshCell Line, Tumoren
dc.subject.meshConserved Sequenceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshReceptors, Immunologicen
dc.titlePhylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentDepartment of Immunology, Oslo University Hospital, Rikshospitalet and University of Oslo, Oslo, Norway.en
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