Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway

2.50
Hdl Handle:
http://hdl.handle.net/10143/125451
Title:
Assessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway
Authors:
Thorn, Fredrik; Celius, Halvor; Odegard, Tone; Mandla, Randeep; Hexeberg, Erik
Citation:
Clinical and Molecular Allergy. 2011 Feb 28;9(1):5

Full metadata record

DC FieldValue Language
dc.contributor.authorThorn, Fredrik-
dc.contributor.authorCelius, Halvor-
dc.contributor.authorOdegard, Tone-
dc.contributor.authorMandla, Randeep-
dc.contributor.authorHexeberg, Erik-
dc.date.accessioned2011-03-23T16:33:41Z-
dc.date.available2011-03-23T16:33:41Z-
dc.date.issued2011-02-28-
dc.identifierhttp://dx.doi.org/10.1186/1476-7961-9-5-
dc.identifier.citationClinical and Molecular Allergy. 2011 Feb 28;9(1):5-
dc.identifier.urihttp://hdl.handle.net/10143/125451-
dc.description.abstractAbstract Background In 2006, the Norwegian Medicines Agency mandated a switch from desloratadine, ebastine, or fexofenadine to cetirizine or loratadine in patients with allergic rhinitis (AR) or chronic urticaria (CU). In an online survey, patients whose medication was switched assessed the impact on efficacy, fatigue, and work productivity/attendance. Methods Allergy patients in Norway completed a 25-item online survey. Patients aged ≥ 18 years with AR or CU who were switched to cetirizine or loratadine from desloratadine, ebastine, or fexofenadine were included. Participants rated post-switch efficacy, fatigue, and effect on work productivity/attendance compared with their pre-switch medication. Patients also reported post-switch change in number of doctor visits required, total treatment cost, and whether they had switched or wanted to switch back to their previous medications. Results Of 1920 patients invited, 493 responded and 409 of these were eligible. Previous antihistamines were desloratadine (78.4% of respondents), ebastine (16.0%), and fexofenadine (5.6%). Post-switch, 64.7% received cetirizine and 35.3% loratadine. Compared with previous therapy, cetirizine and loratadine were rated less effective by 46.3% of respondents; 28.7% reported increased fatigue; and 31.6% reported decreased work productivity with the generic agents. At the time of the survey, 26% of respondents had switched back to their previous medication. Conclusions This is the first survey to assess the impact on patient-reported outcomes of a mandated switch from prescription to generic antihistamines in Norway. The findings suggest that patient response to different antihistamines will vary and that treatment decisions should be individualized for optimal results.-
dc.titleAssessment of efficacy and impact on work productivity and attendance after a mandatory switch to generic second-generation antihistamines: results of a patient survey in Norway-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderThorn et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2011-03-23T16:33:47Z-
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