Comparison of drug concentrations in blood and oral fluid collected with the Intercept sampling device.

2.50
Hdl Handle:
http://hdl.handle.net/10143/119986
Title:
Comparison of drug concentrations in blood and oral fluid collected with the Intercept sampling device.
Authors:
Gjerde, Hallvard; Mordal, Jon; Christophersen, Asbjørg S; Bramness, Jørgen G; Mørland, Jørg
Citation:
Journal of analytical toxicology 2010, 34 (4):204-9
Additional Links:
http://www.jatox.com/index.php/Articles/Comparison-of-Drug-Concentrations-in-Blood-and-Oral-Fluid-Collected-with-the-Intercept%C2%AE-Sampling-Device.html?pop=0

Full metadata record

DC FieldValue Language
dc.contributor.authorGjerde, Hallvarden
dc.contributor.authorMordal, Jonen
dc.contributor.authorChristophersen, Asbjørg Sen
dc.contributor.authorBramness, Jørgen Gen
dc.contributor.authorMørland, Jørgen
dc.date.accessioned2011-01-20T11:50:16Z-
dc.date.available2011-01-20T11:50:16Z-
dc.date.issued2010-
dc.identifier.citationJournal of analytical toxicology 2010, 34 (4):204-9en
dc.identifier.issn1945-2403-
dc.identifier.pmid20465866-
dc.identifier.urihttp://hdl.handle.net/10143/119986-
dc.description.abstractThe aim of the study was to determine drug concentration ratios between oral fluid collected with the Intercept device and whole blood. Samples of blood and oral fluid were obtained from patients admitted to acute psychiatric treatment and drivers suspected of drugged driving. Samples were analyzed for illegal drugs, benzodiazepines, opioids, carisoprodol, and meprobamate. Drugs were detected in samples of both blood and oral fluid from 59 subjects; altogether, 17 different drugs were found. Concentration ratios between oral fluid and blood were determined for all cases. The distributions of drug concentration ratios were wide for most drugs and do not allow reliable estimations of drug concentrations in blood using concentrations in oral fluid. The median oral fluid/blood drug concentration ratios for the most prevalent drugs were 0.036 diazepam, 0.027 nordiazepam, 7.1 amphetamine, 2.9 methamphetamine, 5.4 codeine, 1.9 morphine, and 4.7 tetrahydrocannabinol. The correlation coefficients between drug concentrations in oral fluid and blood ranged from 0.15 to 0.96 for the six most prevalent drugs.en
dc.language.isoenen
dc.relation.urlhttp://www.jatox.com/index.php/Articles/Comparison-of-Drug-Concentrations-in-Blood-and-Oral-Fluid-Collected-with-the-Intercept%C2%AE-Sampling-Device.html?pop=0en
dc.subject.meshAlgorithmsen
dc.subject.meshBlood Chemical Analysisen
dc.subject.meshHumansen
dc.subject.meshReproducibility of Resultsen
dc.subject.meshSalivaen
dc.subject.meshSpecimen Handlingen
dc.subject.meshSubstance Abuse Detectionen
dc.titleComparison of drug concentrations in blood and oral fluid collected with the Intercept sampling device.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentNorwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, Oslo, Norway. Hallvard.Gjerde@fhi.noen
dc.identifier.journalJournal of analytical toxicologyen

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