Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls.

2.50
Hdl Handle:
http://hdl.handle.net/10143/117649
Title:
Bone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls.
Authors:
Gilboe, Inge Margrethe; Kvien, Tore Kristian; Haugeberg, Glenn; Husby, Gunnar
Citation:
2000, 59 (2):110-5 Annals of the rheumatic diseases
Additional Links:
http://ard.bmj.com/content/59/2/110.full.pdf

Full metadata record

DC FieldValue Language
dc.contributor.authorGilboe, Inge Margretheen
dc.contributor.authorKvien, Tore Kristianen
dc.contributor.authorHaugeberg, Glennen
dc.contributor.authorHusby, Gunnaren
dc.date.accessioned2010-12-10T12:53:58Z-
dc.date.available2010-12-10T12:53:58Z-
dc.date.issued2000-02-
dc.identifier.citation2000, 59 (2):110-5 Annals of the rheumatic diseasesen
dc.identifier.issn0003-4967-
dc.identifier.pmid10666165-
dc.identifier.urihttp://hdl.handle.net/10143/117649-
dc.description.abstractOBJECTIVES: To examine bone mineral density (BMD) frequency of osteoporosis and reduced bone mass in systemic lupus erythematosus (SLE), and compare the data of the SLE patients with matched rheumatoid arthritis (RA) patients and healthy controls. Secondly, to study possible correlations between BMD, demographic and disease variables in the SLE patients. METHODS: Measures of BMD assessed by dual energy x ray absorptiometry were obtained from 75 SLE patients aged </= 70 years, 75 RA patients matched for age, sex and disease duration, and from 75 healthy controls matched for age, sex and geographical area. Disease activity and accumulated organ damage were assessed in the SLE patients. RESULTS: The SLE patients had significantly lower BMD values at lumbar spine L2-L4 and hip, and higher frequency of osteoporosis at all sites of measurement compared with matched healthy controls. The matched SLE and RA patients had similar BMD, prevalence of osteoporosis and reduced bone mass. In the SLE patients BMD was more strongly correlated with accumulated organ damage than with markers of disease activity or duration. In multivariate analyses BMD was at all sites predicted by age and body mass, at lumbar spine also by the current corticosteroid dose. CONCLUSION: The study showed reduced BMD in patients with SLE compared with matched healthy controls. Premenopausal women taking corticosteroids were especially affected. Furthermore, the BMD of matched SLE and RA patients was reduced to a similar extent.en
dc.language.isoenen
dc.relation.urlhttp://ard.bmj.com/content/59/2/110.full.pdfen
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759en
dc.subject.meshAbsorptiometry, Photonen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshArthritis, Rheumatoiden
dc.subject.meshBone Densityen
dc.subject.meshCase-Control Studiesen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshGlucocorticoidsen
dc.subject.meshHumansen
dc.subject.meshLupus Erythematosus, Systemicen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMultivariate Analysisen
dc.subject.meshOsteoporosisen
dc.subject.meshPremenopauseen
dc.subject.meshRisk Factorsen
dc.titleBone mineral density in systemic lupus erythematosus: comparison with rheumatoid arthritis and healthy controls.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentOslo City Department of Rheumatology, Diakonhjemmet Hospital, Box 23 Vinderen, N-0319 Oslo, Norway.en
dc.identifier.journalAnnals of the rheumatic diseasesen

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