Comparison of zopiclone concentrations in oral fluid sampled with intercept(®) oral specimen collection device and statsure saliva sampler™ and concentrations in blood.

2.50
Hdl Handle:
http://hdl.handle.net/10143/116379
Title:
Comparison of zopiclone concentrations in oral fluid sampled with intercept(®) oral specimen collection device and statsure saliva sampler™ and concentrations in blood.
Authors:
Gjerde, Hallvard; Øiestad, Elisabeth L; Øiestad, Ase Marit L; Langødegård, Marit; Gustavsen, Ingebjørg; Hjelmeland, Knut; Bernard, Jean-Paul; Christophersen, Asbjørg S
Citation:
Journal of analytical toxicology 2010, 34 (9):590-3
Additional Links:
http://www.jatox.com/index.php/Articles/Short-Communication-Comparison-of-Zopiclone-Concentrations-in-Oral-Fluid-Sampled-with-Intercept%C2%AE-Oral-Specimen-Collection-Device-and-Statsure-Saliva-Sampler%E2%84%A2-and-Concentrations-in-Blood.html

Full metadata record

DC FieldValue Language
dc.contributor.authorGjerde, Hallvarden
dc.contributor.authorØiestad, Elisabeth Len
dc.contributor.authorØiestad, Ase Marit Len
dc.contributor.authorLangødegård, Mariten
dc.contributor.authorGustavsen, Ingebjørgen
dc.contributor.authorHjelmeland, Knuten
dc.contributor.authorBernard, Jean-Paulen
dc.contributor.authorChristophersen, Asbjørg Sen
dc.date.accessioned2010-11-26T11:36:32Z-
dc.date.available2010-11-26T11:36:32Z-
dc.date.issued2010-
dc.identifier.citationJournal of analytical toxicology 2010, 34 (9):590-3en
dc.identifier.issn1945-2403-
dc.identifier.pmid21073813-
dc.identifier.urihttp://hdl.handle.net/10143/116379-
dc.description.abstractA clinical study of zopiclone was performed using doses of 5 and 10 mg. Samples of oral fluid were collected using the Statsure and Intercept devices, and blood samples were collected simultaneously. Concentrations of zopiclone in samples of oral fluid and blood were determined with liquid chromatography-mass spectrometry, and concentrations in undiluted oral fluid were calculated. The concentrations of zopiclone in oral fluid were generally higher when using the Intercept compared to the Statsure device; the median oral fluid/whole blood concentration ratios were 3.8 (range 1.5-15.9) and 1.9 (range 1.2-4.6), respectively (n = 21). The correlation between zopiclone concentrations in oral fluid collected with the two devices was fairly poor, r(2) = 0.35. The results indicate that the type of sampling device may significantly affect the analytical result for zopiclone in sampled oral fluid.en
dc.language.isoenen
dc.relation.urlhttp://www.jatox.com/index.php/Articles/Short-Communication-Comparison-of-Zopiclone-Concentrations-in-Oral-Fluid-Sampled-with-Intercept%C2%AE-Oral-Specimen-Collection-Device-and-Statsure-Saliva-Sampler%E2%84%A2-and-Concentrations-in-Blood.htmlen
dc.titleComparison of zopiclone concentrations in oral fluid sampled with intercept(®) oral specimen collection device and statsure saliva sampler™ and concentrations in blood.en
dc.typeJournal articleen
dc.typepeer reviewed-
dc.contributor.departmentNorwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, P.O. Box 4404 Nydalen, NO-0403 Oslo, Norway. Hallvard.Gjerde@fhi.no.en
dc.identifier.journalJournal of analytical toxicologyen
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