Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis.

2.50
Hdl Handle:
http://hdl.handle.net/10143/114008
Title:
Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis.
Authors:
Hammer, Hilde Berner; Odegard, Sigrid; Fagerhol, Magne K; Landewé, Robert; van der Heijde, Désirée; Uhlig, Till; Mowinckel, Petter; Kvien, Tore Kristian
Citation:
Annals of the rheumatic diseases 2007, 66 (8):1093-7
Additional Links:
http://ard.bmj.com/content/66/8/1093.long

Full metadata record

DC FieldValue Language
dc.contributor.authorHammer, Hilde Berneren
dc.contributor.authorOdegard, Sigriden
dc.contributor.authorFagerhol, Magne Ken
dc.contributor.authorLandewé, Roberten
dc.contributor.authorvan der Heijde, Désiréeen
dc.contributor.authorUhlig, Tillen
dc.contributor.authorMowinckel, Petteren
dc.contributor.authorKvien, Tore Kristianen
dc.date.accessioned2010-10-29T11:17:25Z-
dc.date.available2010-10-29T11:17:25Z-
dc.date.issued2007-08-
dc.identifier.citationAnnals of the rheumatic diseases 2007, 66 (8):1093-7en
dc.identifier.issn0003-4967-
dc.identifier.pmid17234650-
dc.identifier.doi10.1136/ard.2006.064741-
dc.identifier.urihttp://hdl.handle.net/10143/114008-
dc.description.abstractOBJECTIVE: Calprotectin is a major leucocyte protein, shown to correlate well with laboratory and clinical assessments in several inflammatory rheumatic diseases, and large concentrations of calprotectin have been found in synovial fluid from patients with rheumatoid arthritis (RA). The objective of the present study was to examine correlations between calprotectin and joint damage. METHODS: 145 patients with RA were analysed cross sectionally with laboratory (calprotectin, C reactive protein (CRP), and erythrocyte sedimentation rate (ESR)), clinical (28 joint counts (tender, swollen), physician global VAS, DAS28 and RA Articular Damage score (RAAD)), and radiographic (plain hand radiographs; modified Sharp's method) measurements, on the same day. RESULTS: Calprotectin showed a highly significant correlation with measures of joint damage; modified Sharp score r = 0.43 (p<0.001) and RAAD r = 0.40 (p<0.001). The association with modified Sharp score and RAAD score was maintained after adjustment for CRP, ESR, rheumatoid factor, DAS28, sex, and age in a multiple regression analysis (p = 0.018 and p = 0.04, respectively), while neither CRP nor ESR showed any independent associations. Highly significant correlations (p<0.001) were also found between calprotectin and both laboratory and clinical markers of inflammation. CONCLUSION: Calprotectin was found to significantly and independently explain the variation in the radiological and clinical assessments of joint damage. Longitudinal studies are required to examine whether calprotectin may predict the progression of joint damage in RA.en
dc.language.isoenen
dc.relation.urlhttp://ard.bmj.com/content/66/8/1093.longen
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Reumatologi: 759en
dc.subject.meshAgeden
dc.subject.meshArthritis, Rheumatoiden
dc.subject.meshArthrographyen
dc.subject.meshBiological Markersen
dc.subject.meshBlood Sedimentationen
dc.subject.meshC-Reactive Proteinen
dc.subject.meshFemaleen
dc.subject.meshFollow-Up Studiesen
dc.subject.meshHanden
dc.subject.meshHumansen
dc.subject.meshJointsen
dc.subject.meshLeukocyte L1 Antigen Complexen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshRegression Analysisen
dc.subject.meshRheumatoid Factoren
dc.subject.meshSeverity of Illness Indexen
dc.titleCalprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis.en
dc.typeJournal articleen
dc.typepeer revieweden
dc.contributor.departmentDepartment of Rheumatology, Diakonhjemmet Hospital, Box 23, Vinderen, N-0319 Oslo, Norway. h-hammer@diakonsyk.noen
dc.identifier.journalAnnals of the rheumatic diseasesen
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